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HPMC for pharma grade film coating

*It is semi-synthetic in nature, derived from plant cellulose,

*Cross-linking problem with the excipients is totally absent since, the polymer is free from amino acids,

*Can be used for a variety of fill materials containing aldehydic group,

*It readily dissolves in cold water giving a colloidal solution owing to the reversible thermal gelation property,

*Forms a flexible film of controlled dimensions,

*Water does not act as a plasticiser for HPMC.

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Product Details

HPMC (Hydroxypropyl methylcellulose) Capsules are two-piece capsules made from cellulosic raw materials that satisfy vegetarian, religion, cultural and policy needs. These vegetable capsules are an attractive, all-natural dosage form that retain all the advantages - easy to swallow, effectively mask taste and odor, and allow product visibility. HPMC capsules are also starch-free, gluten-free and preservative-free, and meet the strict dietary needs of customers that choose a vegetarian lifestyle. HPMC capsules have been developed for both Health Supplements products and Nutraceutical.

Formula HPMC Specification

Hydroxypropyl Methylcellulose for Plant Capsules

(n-2)/2

OR=-OH、-OCH3、-[OCH2CH(CH3)]nOH or-[OCH2CH(CH3)]OCH3

Plant Capsule Specification

Item			Results
Tightness		grain	≤1
Friability		grain	≤2
Disintegration time limit		min	≤15
Burning residue	Transparent	%	≤2
	Semitransparent	%	≤4
	Opaque	%	≤6
Loss on drying		%	≤8
Heavy metal		ppm	≤10
Arsenic salt		ppm	≤2
Microbial Limit	Total number of aerobic bacteria	cfu/g	≤1000
	Total Mold and Yeast	cfu/g	≤100
	Escherichia coli	cfu/g	Not checked out
	Total Staphylococcus aureus	cfu/g	Not checked out

HPMC Specification

Item			Results
Viscosity	ML-E3	cp	2.4～3.5
	ML-E4	cp	3.6～4.5
	ML-E5	cp	4.6～5.5
pH			5.5～7.5
Insoluble matter in water		%	＜0.4
Loss on drying		%	≤4.5
Burning residue		%	＜1.2
Heavy metal		ppm	＜10
Arsenic salt		ppm	＜2
Methoxy（2910）		%	28.0～30.0
Hydroxypropyl（2910）		%	7.0～12.0
Microbial Limit	Total number of aerobic bacteria	cfu/g	≤600
	Total Mold and Yeast	cfu/g	≤60
	Escherichia coli	cfu/g	Not checked out