Hydroxypropyl methylcellulose (HPMC), HPMC is white or milky white, odorless and tasteless, fibrous powder or granules, the loss on drying does not exceed 10%, can be dissolved in cold water but not in hot water, slowly in hot water Swells, peptizes, forms a viscous colloidal solution, cools to a solution, and accordingly becomes a gel when heated. It is usually used in pharmaceutical excipients and can be used as thickener, dispersant, emulsifier and film-forming agent.
Formula
(n~2)/2
OR=-OH、-OCH3、-[OCH2CH(CH3)]nOH or-[OCH2CH(CH3)]OCH3
Specific application and viscosity range
60YT HPMC | 65YT HPMC | 75YT HPMC | |
50 | 50 | 100 | |
5~50 | 5~50 | ||
35~50 | 35~50 | 35~50 | |
Slow~release | 35~100 | 35~100 | 35~100 |
film | 50~100 | 50~100 | 50~100 |
Capsule sustained~ | 50~100 | 50~100 | |
15~50 | 15~50 |
Specification
Type Item | 60YT HPMC | 65YT HPMC | 75YT HPMC | |
Methoxy % | 28.0~30.0 | 27.0~30.0 | 19.0~24.0 | |
Hydroxypropyl % | 7.0~12.0 | 4.0~7.5 | 4.0~12.0 | |
Gel temperature ℃ | 58.0~64.0 | 62.0~68.0 | 70.0~90.0 | |
Viscosity mPa.s | 3,5,6,15,30,50,4000 | 50, 4000 | 100, 4000,15000, 100000 | |
pH | 5.5~7.5 | |||
Insoluble matter in water | % | <0.4 | ||
Loss on drying | % | ≤4.5 | ||
Burning residue | % | <1.4 | ||
Heavy metal | ppm | <10 | ||
Arsenic salt | ppm | <2 | ||
Microbial Limit | Total number of aerobic bacteria |
cfu/g |
≤600 | |
Total Mold and Yeast | cfu/g | ≤60 | ||
Escherichia coli | cfu/g | Not checked out |
Applied to medical features
This product is a multi~functional pharmaceutical excipient, which can be used as thickener, dispersant, emulsifier, film ~ forming agent, etc. As film coating and adhesive in oral solid preparations, it can significantly improve the stability and dissolution of drugs, and enhance the waterproof of tablets. It can also be used as a suspension aid in suspension, as a matrix material in ophthalmic preparations, as a skeleton material in hydrophilic gel skeleton sustained ~ release tablets and intragastric floating tablets. The indicators comply with USP, EP and Chinese Pharmacopoeia.
HPMC packaging and storage
Barrel or paper plastic bag lined with polyethylene film inner bag. Net weight of each bag: 25kg.
Protect from sun and rain during storage and transportation.
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