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Hydroxypropyl Methyl Cellulose E15 For Tablet Adhesive

When mixed with ethyl cellulose as an organic coating, a strong film with good adhesion can be formed.It has the effect of

covering up the unpleasant taste of drugs.

Lower dosage can make the tablet to achieve higher hardness and lower fragility, the machine pressure is lower when pressing the tablet, can prolong me service life of the equipment.

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Product Details

Hydroxypropyl methylcellulose (HPMC), HPMC is white or milky white, odorless and tasteless, fibrous powder or granules, the loss on drying does not exceed 10%, can be dissolved in cold water but not in hot water, slowly in hot water Swells, peptizes, forms a viscous colloidal solution, cools to a solution, and accordingly becomes a gel when heated. It is usually used in pharmaceutical excipients and can be used as thickener, dispersant, emulsifier and film-forming agent.

Formula

cellulose ether for medicine (n～2)/2

OR=-OH、-OCH3、-[OCH2CH(CH3)]nOH or-[OCH2CH(CH3)]OCH3

Specific application and viscosity range

Viscosity Application	60YT HPMC	65YT HPMC	75YT HPMC
Drug core binder	50	50	100
Tablet isolation	5～50	5～50
Tablet film coating	35～50	35～50	35～50
Slow～release	35～100	35～100	35～100
film	50～100	50～100	50～100
Capsule sustained～		50～100	50～100
Suspension	15～50	15～50

Specification

Type Item		60YT HPMC	65YT HPMC	75YT HPMC
Methoxy %		28.0～30.0	27.0～30.0	19.0～24.0
Hydroxypropyl %		7.0～12.0	4.0～7.5	4.0～12.0
Gel temperature ℃		58.0～64.0	62.0～68.0	70.0～90.0
Viscosity mPa.s		3,5,6,15,30,50,4000	50, 4000	100, 4000,15000, 100000
pH				5.5～7.5
Insoluble matter in water			%	＜0.4
Loss on drying			%	≤4.5
Burning residue			%	＜1.4
Heavy metal			ppm	＜10
Arsenic salt			ppm	＜2
Microbial Limit	Total number of aerobic bacteria		cfu/g	≤600
	Total Mold and Yeast		cfu/g	≤60
	Escherichia coli		cfu/g	Not checked out

Applied to medical features

This product is a multi～functional pharmaceutical excipient, which can be used as thickener, dispersant, emulsifier, film ～ forming agent, etc. As film coating and adhesive in oral solid preparations, it can significantly improve the stability and dissolution of drugs, and enhance the waterproof of tablets. It can also be used as a suspension aid in suspension, as a matrix material in ophthalmic preparations, as a skeleton material in hydrophilic gel skeleton sustained ～ release tablets and intragastric floating tablets. The indicators comply with USP, EP and Chinese Pharmacopoeia.

for medicine hpmc in medicial hydroxypropyl cellulose hpmc for medicine cabinet