Pharmaceutical Excipients HPMC E5 E15


  1. It has excellent water solubility in cold water. 2. It has strong anti-sensitivity, and with the increase of the degree of substitution in the molecular structure, its anti-sensitivity is stronger and more stable;

  2. It has a metabolic character. 

  3. It is relatively stable to acid and alkali5. It has an effective emulsifying effect and can be used as an effective stabilizer and protective colloid;

  4. Its aqueous solution has excellent tablet film-forming properties and is a good coating material for tablets and pills. 



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Product Details

Hydroxypropyl methylcellulose (hpmc), hpmc is white or milky white, odorless and tasteless, fibrous powder or granules, the loss on drying does not exceed 10%, may be dissolved in cold water but not in warm water, slowly in warm water swells, peptizes, forms a viscous colloidal solution, cools to an answer, and for that reason turns into a gel while heated. it is usually utilized in pharmaceutical excipients and can be used as thickenerdispersant, emulsifier and movie-forming agent.


Formula 

cellulose ether for medicine(n~2)/2 

OR=-OH、-OCH3、-[OCH2CH(CH3)]nOH or-[OCH2CH(CH3)]OCH3


Specific application and viscosity range

Viscosity

Application

60YT HPMC

65YT HPMC

75YT HPMC

Drug core binder

50

50

100

Tablet isolation

5~50

5~50


Tablet film coating

35~50

35~50

35~50

Slow~release

35~100

35~100

35~100

film

50~100

50~100

50~100

Capsule sustained~


50~100

50~100

Suspension

15~50

15~50



Specification

                      Type

     Item

60YT

HPMC

65YT

HPMC

75YT

HPMC

Methoxy %

28.0~30.0

27.0~30.0

19.0~24.0

Hydroxypropyl %

7.0~12.0

4.0~7.5

4.0~12.0

Gel temperature ℃

58.0~64.0

62.0~68.0

70.0~90.0

 Viscosity mPa.s

3,5,6,15,30,50,4000

 50, 4000

100, 4000,15000, 100000

pH


5.5~7.5

Insoluble matter in water

%

<0.4

Loss on drying

%

≤4.5

Burning residue

%

<1.4

Heavy metal

ppm

<10

Arsenic salt

ppm

<2

 

 

Microbial Limit

Total number of

aerobic bacteria

 

cfu/g

 

≤600

Total Mold and Yeast

cfu/g

≤60

 Escherichia coli

 cfu/g

Not checked out


Applied to medical features

This product is a multi~functional pharmaceutical excipient, which can be used as thickenerdispersant, emulsifier, film ~ forming agent, etc. As film coating and adhesive in oral solid preparations, it can significantly improve the stability and dissolution of drugs, and enhance the waterproof of tablets. It can also be used as a suspension aid in suspension, as a matrix material in ophthalmic preparations, as a skeleton material in hydrophilic gel skeleton sustained ~ release tablets and intragastric floating tablets. The indicators comply with USP, EP and Chinese Pharmacopoeia.

for medicine  hpmc in medicial  hydroxypropyl cellulose  hpmc for medicine cabinet


HPMC packaging and storage

Barrel or paper plastic bag lined with polyethylene film inner bag. Net weight of each bag: 25kg.

Protect from sun and rain during storage and transportation.

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