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HPMC For Tablet coating

1. It has strong anti-sensitivity, and with the increase of the degree of substitution in the molecular structure, its anti-sensitivity is stronger and more stable;

2. It has a metabolic character. As a pharmaceutical excipient, it is not metabolized or absorbed, so it does not provide calories in medicines and food. It is unique to the low-calorie, salt-free, non-mutagenic medicines and foods needed by diabetic patients. applicability;

3. It is relatively stable to acid and alkali, but if the pH value exceeds 2 to 11, and it is affected by higher temperature or stored for a long time, its viscosity will decrease;

4. It has an effective emulsifying effect and can be used as an effective stabilizer and protective colloid;

5. Its aqueous solution has excellent film-forming properties and is a good coating material for tablets and pills. The film formed by it has the advantages of colorless and tough, and the addition of glycerin can also improve its plasticity.

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Product Details

Hydroxypropyl methylcellulose (hpmc), hpmc is white or milky white, odorless and tasteless, fibrous powder or granules, the loss on drying does not exceed 10%, may be dissolved in cold water but not in warm water, slowly in warm water swells, peptizes, forms a viscous colloidal solution, cools to an answer, and for that reason turns into a gel while heated. it is usually utilized in pharmaceutical excipients and can be used as thickener, dispersant, emulsifier and movie-forming agent.

Formula

cellulose ether for medicine (n～2)/2

OR=-OH、-OCH3、-[OCH2CH(CH3)]nOH or-[OCH2CH(CH3)]OCH3

Specific application and viscosity range

Viscosity Application	60YT HPMC	65YT HPMC	75YT HPMC
Drug core binder	50	50	100
Tablet isolation	5～50	5～50
Tablet film coating	35～50	35～50	35～50
Slow～release	35～100	35～100	35～100
film	50～100	50～100	50～100
Capsule sustained～		50～100	50～100
Suspension	15～50	15～50

Specification

Type Item		60YT HPMC	65YT HPMC	75YT HPMC
Methoxy %		28.0～30.0	27.0～30.0	19.0～24.0
Hydroxypropyl %		7.0～12.0	4.0～7.5	4.0～12.0
Gel temperature ℃		58.0～64.0	62.0～68.0	70.0～90.0
Viscosity mPa.s		3,5,6,15,30,50,4000	50, 4000	100, 4000,15000, 100000
pH				5.5～7.5
Insoluble matter in water			%	＜0.4
Loss on drying			%	≤4.5
Burning residue			%	＜1.4
Heavy metal			ppm	＜10
Arsenic salt			ppm	＜2
Microbial Limit	Total number of aerobic bacteria		cfu/g	≤600
	Total Mold and Yeast		cfu/g	≤60
	Escherichia coli		cfu/g	Not checked out

Applied to medical features

This product is a multi～functional pharmaceutical excipient, which can be used as thickener, dispersant, emulsifier, film ～ forming agent, etc. As film coating and adhesive in oral solid preparations, it can significantly improve the stability and dissolution of drugs, and enhance the waterproof of tablets. It can also be used as a suspension aid in suspension, as a matrix material in ophthalmic preparations, as a skeleton material in hydrophilic gel skeleton sustained ～ release tablets and intragastric floating tablets. The indicators comply with USP, EP and Chinese Pharmacopoeia.

for medicine hpmc in medicial hydroxypropyl cellulose hpmc for medicine cabinet